Fly into Kansai Intl. Airport (KIX), the closest airport, located 22.6 mi (36.4 km) from the city center. If you can't find a flight that works for your travel itinerary, you could book a flight to Itami Airport (ITM), which is 8.4 mi (13.5 km) away.
Consider catching a ride on the metro at Sakaisuji-hommachi Station or Hommachi Station to more easily navigate the city.